Hofmann 重排(降解)

发布日期：2012-11-25 19:58 来源：网络作者：网络浏览次数：

酰胺用溴(或氯)在碱性条件下处理转变为少一个碳原子的伯胺:

[1] A. W. Hofrnann. Ber., 1881, 14, 272.
[2] A. W. Hofmann, Ber., 1882, 15, 407, 752, 762 ; 1884, 17, 1406; 1885, 18, 2734.
[3] E. C. Franklin, Chem. Revs., 1934, 14, 219.
[4] E. S. Wallis and J. F. Lane, Organic Reactions, 1949, 3, 267.
[5] D. E. Applequist and J. D. Roberts, Chem. Revs., 1954, 54, 1083.
[6] V. Franzen, Reaktionsmechandsmen , Heidelberg, 1954, 1, 57.
[7] L. F. Fieser and M. Fieser, Advanced Organic Chemistry, New York, 1961, p 499.